This
page is from a collection of materials
indexed at this website arising from an
investigation and campaign by Brian Deer in The Sunday
Times of London over serious risks and
side-effects from this antibiotic,
marketed under many names, including Septran,
Septrin, Septra, Bactrim, Bactrim DS,
Septra DS, Sulfatrim, SMZ/TMP and
co-trimoxazole. Go to side-effects
homepage
Below is page 19 of a
selection of mail to this website. If you
want to read of bad experiences, start
with selected letters to The Sunday Times
at this link. Most users have
no problems, but feel free to share your own
experience, which may help others. Please
note that Brian Deer is a journalist and
that this site has many visitors. He
finds it quite difficult to keep on top
of detailed questions
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BACTRIM:
23 November 2005
Hello, Brian
I am so glad to have come across your wed site
for this situation. My 24 year old sister was
prescribed Bactrim for a staph infection. The
infection cleared up very quickly. Her doctor put
her in the hospital for IV antibiotics. She was
told to go home and continue to take the Bactrim.
She became so ill for the last four weeks we have
had to bring her to the ER several times and
today she is still in the hospital. All blood
work shows no sign of the staph infection which
started out on the lower part of stomach area.
When it started three weeks ago she begin with
severe pain through out her body and feeling very
sick. She had the shakes she is still numb from
her neck up and can not taste anything. Her blood
pressure when she stands up is 60 that is why she
is still in the hospital. A cardiologist is
seeing and treating her for that. She is not in
as much pain as before but still very exhausted
just to sit up in bed is hard for her. They have
ran so many test MRI, EKG, blood work, urinalysis
every test has come up nothing. They do not see
any reason why she is still so ill and we have
mentioned the medication to them and no one seems
to think this is still the reaction causing the
problem. Could you please let me know if people
are this ill for this long with reactions to this
nightmare of a medication that needs to be taken
off of the market so no one else or their family
has to go through this. She was a perfectly
healthy 24 year old with no known health issues.
She is getting very depressed and has anxiety
quite often. Please share any info you have on
how long this could take. Also if you know of any
one that had trouble with extremely low blood
pressure and very fast pulse rate... Everyday we
wake up and say maybe today will be the turning
point for her but this has not happened yet. She
now has seizure type shakes in the morning that
she can not control...this maybe be due to the
blood pressure meds he is giving her to bring her
pressure up. Please help us maybe understand this
better and it this will go away..
Thank you
Dawn
CO-TRIMOXAZOLE:
28 November 2005
Dear Brian
I had my
first experience with this antibiotic in July
this year. The day after finishing a 7 day course
I awoke about 4am with a grumbling stomach. That
was July 24th 2005. It is now November 28th and
my stomach still grumbles but I have also had
fatigue, and trembling legs something like RLS. I
am 59 year old and was prescribed these for
bronchitis. Some days in August and September my
brain didnt function properly and it did not feel
like I was real. I have always been quite a fit
fellow and tramp the hills and mountains but find
now I dont have the energy I manage about 5 hours
at work until I get fatigued and my stomach
growls and legs tremble.
Kindest
regards
Glen
G, Christchurch, NZ
SEPTRA:
29 November 2005
Brian -
I have read
many of the e-mails on your website...I can
empathize with Denise from Manhattan, as my wife
was prescribed Septra, by a nurse practitioner,
for a supposed urinary tract infection. We have
since discovered by a regular visit to the OBGYN,
because my wife is 8 months pregnant, that the
lab results actually didn't show a UTI - and that
the OBGYN says the hospitals sometimes do this -
prescribe something just to get you out of there
(we went to the ER, because we thought it was
premature labor). The thought of a UTI came about
because my wife was urinating about every 30
mins. Well, needless to say, the OBGYN has taken
my wife off the Septra, after having taken it for
8 days, 2x per day) and God willing, we won't be
faced with severe side affects to my wife or our
unborn son (we haven't had any problems yet, only
minor nausea). I am nevertheless frustrated at
the hospital, and regret not speaking up when my
gut told me to do so. The nurse didn't give good
enough evidence to us that the UTI really existed
- she was vague in telling us that my wife had a
UTI, and quickly told us she was prescribing us
Septra to cure it. Now, unfortunately, I again
have to go back to not being able to trust yet
another group of people (nurses / hospitals), as
I had hoped to get away from...
Patrick,
Sacramento, CA
BACTRIM:
29 November 2005
Hi there
Brian
I had the
worst experience of my life when I was prescribed
Bactrim for a sinus infection. Twenty minutes
after taking this I felt my arms going numb and
drove myself to the local emergency room. By the
time I arrived there I could barely get out of my
car and had to be taken inside in a wheelchair. I
was unable to even hold onto a phone! I was
admitted and had to be given potassium by IV
since my levels had dropped so low. I spent 3
days in the hospital from only ONE dose of this
stuff. The doctor could not believe that this
drug could do THAT to me...........I was one of
the RARE few that this drug affects
neurologically. I not only lost strength in my
hands and legs but my heart at a resting state
was racing and my pulse was over 138 beats a
minute......(it normally is 64) After being
released I went to the local chiropractor and did
not tell him what happened but told him of pains
I was experiencing through out my body ....I told
him I had pain even across my face...........he
said the only thing that would cause the pain in
my face was from a toxic substance I must have
ingested!!!! Imagine that! I then told him what
had taken place.....I fear that if I EVER had
this drug again ..it would indeed kill me!
One thing I
must add is that I am a very physically fit
individual and not overweight etc. so for this to
happen to me really scared me. I hope anyone that
is given this, is aware of just how bad things
can get in a very short amount of time..........I
wish I had known!!!!!!!!!
Angel
R
BACTRIM:
29 November 2005
I took
Bactrim for bad skin infection on my arm. The
doctor said it was cellulitus. I was told to take
one tablet every 12 hours for 10 days even the
condition is all better. My skin condition was
all better by about 5 days later, but I kept
taking the medication. Through out the course of
medication, I started to have vertigo and
fatigue. I also felt nauseous, too. On the 7th
day in the morning, I saw a hullucination as I
saw my landscaper in my yard. I saw him with four
arms! I blinked my eyes hard and shook my head
but my vision took more than a few seconds to
normalize. I went right back to bed.
Suddently on
the 8th day in the morning as I was eating a bowl
of cereal, my right thigh started to get very
itchy. I looked at my thigh and there were red
and purple hives all over my
thigh. I panicked and within a couple of hours
the hives spread all over my body. I went to an
emergency room and they told me to stop taking
it. That night, I had chills and fever over 101.
My joints were in pain and I thought I was going
to die.
Next day, I
went to my family doctor and she took blood for a
test. My white blood cell count was very low. To
treat the condition, I was told to stop taking
the drug. Also, I was prescribed to take
METHYLPREDNISOLONE tablets (4mg). I took them as
I was told and I took a lot of rest and ate a lot
of vegitables, white meat, garlic, and euchanatia
tea. I got all better in 2 - 3 days.
I will never
take this drug again. If you have ANY concern is,
if you think you feel any of the symptom I
described, stop taking it and GO SEE A DOCTOR
immediately.
Anon
BACTRIM:
5 December 2005
Dear Brian:
Thank you
for this website. My 66 year old sister took a
low dose course of Bactrim for a UTI while
traveling last month. She had no apparent
problems but the UTI returned once she was back
home in the UK. She was then prescribed a high
dose of Trimethoprim alone. Within 2 hours of
taking the first dose, she started getting the
acute nausea, weakness and headache associated
with the Bactrim reaction. She stopped taking the
Trimethorpim immediately, but it's now 4 days
later and the headache has worsened, the nausea
is still bad, she's had the fever and chills and
is now so weak she can't get out of bed. Doctor
is coming today. When she called the surgery two
days ago, they prescribed a cephalosporin
instead, but I've had an anaphylactic reaction to
those, so she doesn't want to start on something
that may cause more problems. I'm the other side
of the world and, having read through your site,
I am really worried about her.
C W
BACTRIM:
14 December 2005
Hello Brian!
Congrats on not only your articulate and
effective article, but also on the courage you've
shown by producing it. I'd like to share a story
about Bactrim. I was diagnosed with a UTI a week
ago roughly, and was prescribed Bactrim. The
first day, I felt great, but strange. This sounds
weird, but it was like I was in my own little
world, and I was extremely giggly. Well that
ended quickly. The second day, I noticed I felt
extremely tired and not in pain, but stiff. My
coordination was off and I noticed right away,
because I waitress in the mornings, and I dropped
things all shift, and couldn't hold my focus.
I was
forgetting everything, and that's very unusual.
On the third day I woke up and noticed my skin
hurt. Nothing was red, but it felt like a
sunburn. I actually couldn't sit on the toilet to
urinate because the seat hurt my skin. I
basically had to hover over it. I felt like one
big walking sore bruise. I don't know why, but I
never made anykind of connection. You usually
take what your doctor gives you and you're good
to go. That, and I had never had any kind of
reaction to antibiotics in the past. Well on both
the 4th and 5th days of my dosage, (2 tablets/day
for 5 days) I started getting shooting pains in
my left leg.
I have a
follow up appointment today, and I am definitely
planning on telling my doctor about this. I have
been freezing (walking around w/ literally 3
pairs of socks on) and my appitite was gone for
the whole time. I am getting that back now. I
don't understand why this drug is still given, or
why there hasn't been more done about it. I
commend you for your efforts.
Sherry,
PA
SMZ-TMP:
14 December 2005
I got
cryptoccocal meningitus because my immune system
was suppressed due to my having hemolytic anemia.
I was put on a multitude of drugs one of which
was SMZ-TMP. I came out of the hospital on 90mg
of Prednisone, that was July 23, 2005. For
approxiamately five weeks I've been breaking out
in a rash that has continually gotten worse and
itches really bad. At this point I'm down to 20mg
of Prednisone but the rash practically covers my
whole body. My infectious disease doctor took me
off the SMZ-TMP yesterday thinking that might be
the culprit.
Lisa
C
SULFATRIM
DS: 15 December 2005
Mr. Deer,
I found your
website as I was searching the web for sulfatrim
side-effects. I have to admit it was really
helpful since it reveals accurate symptons and
not only theoritical side-effects.
Here's my
story. I am 27 years old and last Thursday I
consulted my doctor for a UTI and he prescribed
sulfatrim, twice a day for 10 days. The next few
days were not that bad, my health seemed to
improve. On Tuesday night I started having chills
and I suddenly felt very tired. Then fever
appeared. Wednesday morning I noticed a few red
spots on my chest. At night things had gone worse
: fever, muscle ache, extremely sensitive skin,
red ithchy spots from head to toe, serious neck
pain, swollen ganglions, a sore throat, short
breath, no energy at all and backpain in the left
kidney area.
I went to
the doctor today, he prescribed complete rest for
5 days, had my blood tested and I'm going back on
Monday for a check-up. Being aware of my health
background; I have been hospitalized for left
kidney infection last summer and my mother
suffers from severe kidney problems...this
worries me a little. The side-effects of
sulfatrim are absolutely not worth the risks of
taking this drug. And since the side-effects are
not necessarily clearly stated, I consider this
drug very dangerous. Experiences like mine and
those of so many other people cannot be left
unsaid.
Thank you,
Nancy
B
BACTRIM:
19 December 2005
Brian, I
wanted to share my experice because it is
different than most i have read on your site. I
had taken Bactrim straight for about 2 years to
clear up acne and keep it away, this was the only
thing that worked for me( in combination with
Retin A and Benzoil peroxide ) I stopped taking
it because i didnt like the idea of taking it all
the time. , and eventually my acne came back. I
took it again for another 2 years or so, and it
worked well again... eventaully i wanted to stop
taking it again... and back came the large
pimples. So once again i went on it.. acne began
to clear up but this time i had side effects. I
began to get a bloody mucusy stool... it lasted a
month or so even after i stopped taking the med.
i also got a minor yeast infection in my penis
that went away away when i stopped Batrim..
anyway i went to a GI doc, he suggested that a
diff type of bac had taken over when the
"good bact" where killed
inadvetantly..He said it wouldnt make a diff if i
continued to take Bactrim so i stared taking it
again (i hate pimples) i got tested for the other
bactiria but, it was not there,however i also
stopped having the sysmtoms by then.. and i
started taking Bactrim again at this time.. now
here i am still on bactrim and i have what could
be another side effect/.. the past week or 2 i
started gettin little itchy bumps, kind of like
poison ivy, kind of like aquatic dermatosis... I
thought it was the second of the 2 because i go
in the ocean alot, and have had it.. anyway now i
think it may be from Bactrim...so im not sure
what to do!!!!!! ill let you know how it works
out...
john
BACTRIM:
20 December 2005
I started
taking this med last Wednesday for a common sinus
infection. I took two each day until I woke up
Sunday with severe nausea. I have stopped taking
it but so far (this is early Tuesday morning), no
improvement. I'm also beginning to be very very
sore in most joints.
Jan
S
BACTRIM:
21 December 2005
Hello, i am
a 20 yr old female, otherwise healthy who was
prescribed bactrim for a sinus infection. I took
6 days worth and then began to feel
chills...tookanother days worth and got hives...
really really itchy and cover me from head to toe
hives. I stopped taking the bactrim, but at what
point should i worry.
do symptoms
typically worsen from here.. ???
Dierdre
H
AP0-SULFATRIM:
22 December 2005
Hi Brian,
I just spent
the past hour reviewing your very interesting,
informative site.
I had a UTI
a three weeks ago. Took Apo-Sulfatrim for three
days. After taking the first pill, 15 mins later,
like hitting a brick wall, I experienced the most
intense vaginal itch ever. I have heard before
that yeast and bladder infections go hand in hand
and didn't give it too much thought. Went back to
the pharmacy and purchased a 1 day Canasteen
application. I was surprised though how strong
and quick it came on.
Immediately
my bladder infection started to feel better after
the first antibiotic. The vaginal itch continued
for two more straight days, keeping me up
throughout the night and bedridden, therefore
missing work. Finally on the eve of the second
day I called a pharmacist to get their opinion as
to whether the antibiotic could be causing this
and whether I should retreat the yeast infection.
The response, continue the antibiotics and if I
don't feel any better go to a doctor tomorrow. So
on the third and final day of the antibiotic
treatment I went to the see a doctor at a clinic.
To my surprise he told me to take my last pill
and to retreat the yeast infection with a 6 day
application. The physician never did a physical
exam. Could not believe it! If he had he would
have know it was not a yeast infection. I even
spotted blood which I suspect came from the
intense irritation. I finished the course of my
pills and Canisteen and within two days after the
antibiotic, I started to heal.
Nine days
after taking my last Apo-Sulfatrim my bladder
infection returned. After struggling all day with
it that eve I took another antibiotic, and low
and behold the vaginal itch returned within 15
mins. Needless to say I did not take another pill
and I had my confirmation that the itch was an
adverse reaction. I was in discomfort for three
more days. I was so angry especially with the
physician, as well as the Pharmacy Pamphlet which
neglected to highlight any effects related to
vaginal itch.
Three weeks
after taking my last pill, my GERD is out of
control. I am normally on Pantoloc daily and that
is making no difference. My stomach is burning,
it feels like someone punched me and I am
nauseas. I suspect these symptoms are remnants of
the antibiotic. Do you have any idea how long it
takes to leave your system?
Thanks,
Kellie
M. Ontario, Canada
SEPTRA:
22 Dec 2005
Hi, my Dr
prescribed Hydrochlorothiazide which is a water
pill for high blood pressure last March I was
told by the pharmacist's that it contained Septra
which my Dr knows that I am very allergic to, the
pharmacist phoned my Dr as they know that I am
allergic to that drug and there is a certain
amount of Septra in the drug I was told it was
just a small amount I was prescribed 25mg to be
halfed and half taken in the mornings a few weeks
later I developed burning sensation in my legs
and my tongue was covered with ulcers it has
gradually been getting worse and now I have
terrible sweats and get really dizzy,feel very
weak and breathless my whole body feels its on
fire I have to be careful what I eat or I get
stomach pains I can't sleep at night I feel
frustrated and depressed as the Dr can't tell me
what is wrong with me.
sincerely,
Ailsa
S
SULFATRIM:
24 December 2005
To: Brian
Deer
I often have
bladder infection my Dr. prescribed Cypro which
worked very good until the bacteria became immune
to the antibiotic,he then prescribed
APO-sulfatrim-DS after taking the first dose my
face started itiching my lip broke out in what
looked like a cold sore and I had different rash
spots on my face and one eye after I stopped
taking it these side effects went away.It sure
was,nt fun.
Wayne
M
SEPTRA:
27 December 2005
I am writing
this email because I have never experienced any
allergic reaction in my life to antibiotics. I
have taken a few doses of septra for a recurring
UTI and my entire body was covered in hives.
These hives were more like large welts, and
lasted for several days. As uncomfortable as this
rash and burning itching was, I am more upset
over the terrible peeling scaling skin. I now
have patches on my chest, arm, lips, and chin. No
amount of moisturizers, Vaseline, or creams seem
to stop the peeling dry skin and pain. Is there
anything you can suggest?
Melissa
C
SMZ/TMP:
28 December 2005
Dear Brian,
My husband
was diagnosed with having a prostate infection
and POSSIBLY a urinary tract infection. The
doctor gave him ten samples of Levaquin 750 mg.
He also prescribed Flomax .4mg in tablet form,
along with SMZ/TMP DS 800/160 to be taken 2x
daily for 20 days. (to be taken after the
Levaquin was gone.)
He started
taking the septra on the 20th of December, and
continued taking the drug for 5 days. On day 4,
he started feeling weak and had the all-over
blahs . The next day, he still had those
symptoms, along with loss of appetite, chills
with uncontrollable shakes, profuse sweating, and
inability to sleep even though he was exhausted.
He stopped
taking the drug after I did some research and
came to your website. I was appalled at what I
read and angry at the doctor who prescribed this
to him. My husband has already had two heart
attacks in his life; he doesn t need another. He
also takes meds for that, which makes me wonder
if the doctor even took that into consideration.
I m sure he did, but I still wonder why he would
prescribe something that he most likely has no
clue about the side effects or he s one of those
that doesn t care, just wants his money.
We called
the doctor back to inform him that my husband was
having these awful side effects. His nurse called
back to inform us that they would call in a new
prescription, however, never even bothered to ask
what side effects he was experiencing. She asked
no questions nor did she provide any other
information.
The new drug
is Cephalexin 500 mg generic for Keflex. I haven
t done as much research on this one yet, as my
husband s not going to take it until he starts
feeling better and getting over the effects of
the septra. Any information you can provide on
this drug will be greatly appreciated.
Also, I
would like to know if you can offer up some ways
to get him feeling better quicker. It s been two
days now that he has not taken the septra and is
still feeling ill.
Are there
certain foods or drinks he can take that would
help quickly? I ve got him on ensure to at least
replace lost vitamins and minerals, but am having
a hard time getting him to drink lots of liquids
or eat anything.
Thanks,
Melinda,
Nashville, TN
SEPTRA:
30 December 2005
I started
septra 5 days later my tongue started itching and
swelling well the next day when I woke up , my
neck glands looked like golf balls its been 4
days since I have stoped taking the septra and my
toungue amd neck are getting worse I am on
aumentan for a sinus infection and have been
using this drug for years no problems I know that
septra has done something to me is there a time
frame for the sulfites to leave ? this sucks I
look like someone with a tumor on my neck Thanks
for any help very painful
Tony
T
SEPTRA:
30 December 2005
Hello,
I took
Septra about two weeks ago for a UTI and had no
side effects. Then a week and a half later I
suddenly received a fever that started off with a
white tongue, light sneezing that all disappeared
except for the fever. I have this fever still and
it is going on day 10. I do not have any rashes.
I feel hot on the top of my back and on the top
of my hands. My normal body tempertature is 96-
my fever has been between 97.2-98.5. Could this
be the effects of Septra? Is there a way to flush
this out of my system completely before it gets
worse? I am 29 year old female with no health
problems. Thank you
Jenny
F
BACTRIM:
5 January 2006
Great site.
After having some nasty side effects from this
drug, I wonder in your experience, what is the
average time for it to be flushed from one's
system. I had the typical itching, burning,
dizzyness, and now I have been off it for about
three days and still have numbness in my feet and
a sore back (which might not be from the
bactrim). It did knock out my epydidimitis, but
was a tough drug to take.
Ryan
C, Fort Worth, Texas
SEPTRA:
6 January 2006
Hello:
When my
daughter was 3 years old, she started getting
recurring pneumonia, many drugs were tried and
tested. All of a sudden, after a year and a half
of pneumonia, endless tests and tribulations, my
daughter's illness suddenly went away. Relieved?
No, it was the beginning of an even worse
nightmare. With each day that passed, my daughter
grew weaker and developed a strange hue of skin.
I took her
back to her doctor who ordered blood tests, my
daughter needed an immediate transfusion of
packed red blood cells or she would die. From
then until now, she is ten years old now, she has
needed monthly transfusions. The specialists
finally diagnosed her with Acquired Red Cell
Aplasia (Her bone marrow was incapable of making
red blood cells.). I wondered and drove myself
nearly crazy trying to find out what caused this.
It was decided that the antibiotics she was on
for nearly two years caused the bone marrow
failure. What drugs had she taken? Augmentin and
Septra. Was the treatment for the pneumonia a
life saver or a killer? Time will tell, I just
want people to be aware of the many risks
associated with these drugs. Don't think this
could never happen to you or your family, that's
what I used to think.
Sincerely,
Jennifer
F
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