BRIAN DEER:
MONKEY BUSINESS Page
3
Countdown
to disaster
January 27
2006 Medicines and Healthcare products
Regulatory Agency (MHRA) gives permission for human
trials of antibody drug TGN1412
February
22 volunteers selected for trial
March 13 TGN1412
administered in trials at Northwick Park hospital,
London. The six men’s immune systems react to
drug with disastrous “cytokine storm”,
resulting in agonising, life-threatening injuries
May 25
MHRA inquiry finds “unexpected biological
effect” most likely cause of incident
June 27
Ryan Wilson, most seriously injured victim, leaves
hospital
July 19
Wilson returns to hospital to have toes amputated
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