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TeGenero's TGN1412 drug trial

The Sunday Times

Monkey business

Countdown to disaster

January 27 2006 Medicines and Healthcare products Regulatory Agency (MHRA) gives permission for human trials of antibody drug TGN1412

February 22 volunteers selected for trial

March 13 TGN1412 administered in trials at Northwick Park hospital, London. The six men’s immune systems react to drug with disastrous “cytokine storm”, resulting in agonising, life-threatening injuries

May 25 MHRA inquiry finds “unexpected biological effect” most likely cause of incident

June 27 Ryan Wilson, most seriously injured victim, leaves hospital

July 19 Wilson returns to hospital to have toes amputated

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TeGenero's TGN1412 drug trial
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This report is copyright, Brian Deer. No portion of this article on Ryan Wilson and the TGN1412 drug trial may be copied, retransmitted, reposted, duplicated or otherwise used without the express permission of the author. Responses, information and other feedback are appreciated