Campaign win
At the conclusion of the campaign, the UK’s Committee on Safety of Medicines and Medicines Control Agency announced in July 1995 a change in the drug’s indications. This change was reflected in the “uses” section in its data sheet, set out below.
| BEFORE THE CAMPAIGN: Uses. Septrin is an antibacterial agent. Septrin is effective in vitro against a wide range of Gram-positive and Gram-negative organisms. It is not active against Mycobacterium tuberculosis. Mycoplasma or Treponema pallidium. Pseudomonas aeruginosa is usually insensitive.
Septrin is of value in the treatment of the following: Respiratory tract: Acute and chronic bronchitis, bronchiectasis, lobar and broncho-pneumonia, otitis media. sinusitis and prevention and treatment of Pneumocystis carinii pneumonitis. Genito-urinary tract: Acute upper and lower urinary tract infections, bacterial prostatitis and male and female gonorrhoea. Gastro-intestinal tract: Typhoid and paratyphoid fevers, chronic carriage of Salmonella typhi and paratyphi, cholera as an adjunct to fluid and electrolyte replacement and shigellosis. Skin infections: Pyoderma, abcesses and wound infections. Other bacterial infections: Acute and chronic osteomyelitis, acute brucellosis, septicaemias and other infections caused by sensitive organisms. |
AFTER THE CAMPAIGN: Uses. Septrin should only be used where, in the judgement of the physician, the benefits of treatment outweigh any possible risks; consideration should be given to the use of a single effective antibacterial agent.
The in vitro susceptibility of bacteria to antibiotics varies geographically and with time; the local situation should always be considered when selecting antibiotic therapy. Treatment and prevention of Pneumocystis carinii pneumonitis (see Dosage and administration and Side- and adverse effects). Treatment and prophylaxis of toxoplasmosis, treatment of nocardiosis. Urinary tract infections; Acute uncomplicated urinary tract infections: Treatment of urinary tract infections where there is bacterial evidence of sensitivity to co-trimoxazole and good reason to prefer this combination to a single antibiotic. Respiratory tract infections; Otitis media: Acute treatment of otitis media, where there is good reason to prefer co-trimoxazole to a single antibiotic. Treatment of acute exacerbations of chronic bronchitis, where there is bacterial evidence of sensitivity to co-trimoxazole and good reason to prefer this combination to a single antibiotic. |
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