| |
August
1997
|
February
1998
|
Average
interval reported
between MMR shot and onset of behavioural
symptoms |
14 days |
6.3 days |
| Range of
intervals reported between MMR shot and
onset of behavioural symptoms |
1 - 56 days |
1 - 14 days |
| No. children
whose parents associated onset of child's
behavioural symptoms with MMR |
9 of 12 |
8 of 12 |
| Child 4: age
of onset of behavioural problems the
parent associated with MMR |
2.5 years |
4.5 years |
No. children
whose colons
were endoscopically normal |
6 of 12 |
4 of 12 |
No. children
in whom focal
acute colonic inflammation was
found histologically |
2 of 12 |
5 of 12 |
No. children
with "red halo"
around lymphoid follicles |
2 of 12 |
4 of 12 |
No. children
with "patchy
chronic inflammation in the colon"
(histology) |
8 of 12 |
11 of 12 |
Child 8:
endoscopic findings
[The only girl in study] |
Normal |
Prominent ileal
lymph nodes |
| Child 8:
histologic findings |
Normal |
Acute and chronic
non-specific colitis;
reactive lymphoid
nodular hyperplasia |
No. children
with histologi-
cally reactive ileal lymphoid hyperplasia
(10 biopsied) |
10 of 10 |
7 of 10 (text)
8 of 10 (table) |
| No. children
with urine tested for methylmalonic acid |
11 of 12 |
8 of 12 |
No.
ileo-colonic biopsy series
from matched controls with histologically
normal mucosa |
10 |
5 |
| No. controls
tested for urinary methylmalonic acid |
12 |
14 |
No. children
who didn't under-
go psychiatric assessment
at the Royal Free |
3 of 12 |
4 of 12 |
| First sentence
|
We present the first
12 children, investigated for a new
syndrome comprising chronic enterocolitis
and regressive behavioural disorder. |
We investigated a
consecutive series of children with
chronic enterocolitis and regressive
developmental disorder. |
| Conclusions/interpretation |
We have identified
signif-icant gastrointestinal pathology
in association with behavioural regres-
sion in a selected group of previously
apparently normal children... |
We identified
associated gastrointestinal disease and
developmental regression in a group of
previously normal children... |
| Discussion on
selection bias |
Intestinal and
behaviour-al pathologies may have
occurred together by chance, reflecting a
selection bias. |
Intestinal and
behaviour-al pathologies may have
occurred together by chance, reflecting a
selection bias in a self-referred group. |
No. children
reported
with constipation |
0 |
0 |