| |
August
1997
|
February
1998
|
Average
interval reported
between MMR shot and onset of
behavioural symptoms |
14 days |
6.3 days |
| Range
of intervals reported between MMR
shot and onset of behavioural
symptoms |
1 - 56 days |
1 - 14 days |
| No.
children whose parents associated
onset of child's behavioural
symptoms with MMR |
9 of 12 |
8 of 12 |
| Child
4: age of onset of behavioural
problems the parent associated
with MMR |
2.5 years |
4.5 years |
No.
children whose colons
were endoscopically normal |
6 of 12 |
4 of 12 |
No.
children in whom focal
acute colonic inflammation was
found histologically |
2 of 12 |
5 of 12 |
No.
children with "red
halo"
around lymphoid follicles |
2 of 12 |
4 of 12 |
No.
children with "patchy
chronic inflammation in the
colon" (histology) |
8 of 12 |
11 of 12 |
Child
8: endoscopic findings
[The only girl in study] |
Normal |
Prominent
ileal
lymph nodes |
| Child
8: histologic findings |
Normal |
Acute and
chronic
non-specific colitis;
reactive lymphoid
nodular hyperplasia |
No.
children with histologi-
cally reactive ileal lymphoid
hyperplasia (10 biopsied) |
10 of 10 |
7 of 10 (text)
8 of 10 (table) |
| No.
children with urine tested for
methylmalonic acid |
11 of 12 |
8 of 12 |
No.
ileo-colonic biopsy series
from matched controls with
histologically normal mucosa |
10 |
5 |
| No.
controls tested for urinary
methylmalonic acid |
12 |
14 |
No.
children who didn't under-
go psychiatric assessment
at the Royal Free |
3 of 12 |
4 of 12 |
| First
sentence |
We present the
first 12 children, investigated
for a new syndrome comprising
chronic enterocolitis and
regressive behavioural disorder. |
We
investigated a consecutive series
of children with chronic
enterocolitis and regressive
developmental disorder. |
| Conclusions/interpretation |
We have
identified signif-icant
gastrointestinal pathology in
association with behavioural
regres-
sion in a selected group of
previously apparently normal
children... |
We identified
associated gastrointestinal
disease and developmental
regression in a group of
previously normal children... |
| Discussion
on selection bias |
Intestinal and
behaviour-al pathologies may have
occurred together by chance,
reflecting a selection bias. |
Intestinal and
behaviour-al pathologies may have
occurred together by chance,
reflecting a selection bias in a
self-referred group. |
No.
children reported
with constipation |
0 |
0 |